Even medicines that are years past their expiration date and haven't always been kept in strict climate-controlled conditions may still retain their original potency، a small study suggests.
That is good news for people working in remote areas of the world where sometimes an expired medication is the only one available and the alternative is having no way to treat a serious illness، the study authors write in the journal Wilderness & Environmental Medicine.
'The expiry date on a drug packet is the last date a drug company will guarantee the drug content and stability when stored in the recommended conditions and in the original packaging،' said lead study author Dr. Emma Browne of the British Antarctic Survey Medical Unit in Plymouth، UK.
'This date is not necessarily the point at which the drug becomes ineffective or dangerous، and for many medications، this window may be far longer than the usual two-to-three-year expiry date،' she told Reuters Health. In some parts of the world، doctors face the difficulty of getting medicine more than once a year. It can also be costly for small communities or expedition groups to replace unused drugs 'just in case،' she added.
'The doctor must decide if it is safer to give an out-of-date medication or not treat a condition and hope the person gets better، which is a huge ethical dilemma،' she said. 'As we push the boundaries of exploration، for example with missions to Mars، the long-term stability of medications becomes even more important.'
The study team tested the stability of five expired drugs that had been returned from the British Antarctic Survey، which operates five bases and two ships in the Antarctic region and has on-site medical and dental facilities. Drugs for the Antarctic operation are ordered annually in May and shipped from the UK in September، arriving at the bases in December after spending several months at sea، the researchers note.
The fresh drugs sent to the Antarctic are transported in the ship's hold، which is not temperature controlled، and the ship passes through the tropics for approximately three weeks، then ultimately drugs are transported to the base in temperatures far below freezing. The drugs tested by Browne's team made this trip a second time، when they were returned because they had passed their expiration date، the authors add.